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KMID : 0364820210570030142
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Korean Journal of Microbiology
2021 Volume.57 No. 3 p.142 ~ p.153
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Postbiotics for cancer prevention and treatment
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Kim Suk-Jin
Kim Gun-Hee
Cho Hyo-Sun
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Abstract
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The incidence of cancer has been rising expeditiously, and postbiotics have been receiving great attention from researchers for cancer therapy due to the side effects and complications of conventional cancer treatment. Postbiotics encompass a wide range of complex macromolecules such as inactivated microbial cells, cellular fractions or metabolites and provide various physiological health benefits to the host. Postbiotics exert anticancer effects by apoptosis, anti-proliferative and anti-inflammatory effects, as well as modulating the composition of the gut microbiota and the immune system. This review provides an overview of the conceptual and safety issues surrounding postbiotics, highlighting their biological role in the prevention and treatment of cancer.
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KEYWORD
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apoptosis, cell cycle, gut microbiome, human cancer, immune system, postbiotics
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